Workers may be harmed from exposure to nickel. Nickel deficiency can cause diseases such as diabetes, anemia, cirrhosis, uremia, renal failure, abnormal metabolism of liver lipids and phospholipids. First, nickel causes essential metal imbalances and severely disrupts enzyme action and regulation. The Effects of Nickel on Human Health. Nickel deficiency has not been reported in people, although it may exist, since nickel deficiency has been seen in animals. Exposure to nickel may lead to cancer. A nickel allergy is the body’s adverse immune response when someone comes into contact with a product containing nickel. Normally, the adult body contains about 10mg of nickel. Taking trace amounts of nickel in a supplement is effective for preventing nickel deficiency. The patient may experience asthma attacks, pulmonary fibrosis , and chronic bronchitis . About 10% of women and 2% of men are highly sensitive to nickel. Some of these toxic symptoms include: Preventing nickel levels in the body from getting too low (nickel deficiency). Nickel is an essential element of the human body, and its content is extremely small in the human body. Health effects. Metabolism and Absorption of Nickel When nickel enters the body it is distributed to all organs, but mostly in the kidney, bone, and lungs (Samal and Mishra, 2011). Chronic noncancer health effects may result from long-term exposure to relatively low concentrations of pollutants. Certain amounts of nickel are useful to the human body, but too much nickel can be toxic. Nickel has been found to have some adverse systemic effects on the body. Respiratory Conditions: Exposure to nickel may also cause systemic effects. It also contributes to a high amount of oxidative stress. Normally, the immune system defends the body … The level of exposure depends upon the dose, duration, and work being done. Exposure can harm the lungs, stomach, and kidneys. Inhalation of nickel also can cause cancer of the lungs, nose and sinuses. Nickel is a common metal that can cause many of these problems. If you've been exposed to large amounts of nickel, and believe it to be affecting your health, it is important to take proper measures to get your body back in balance. Nickel, which enters the blood stream is General Nickel Toxicity Information Nickel is a silver-white metal found in the earth’s crust that is used to produce steel, nickel-cadmium batteries, heating fuel, nickel plating and ceramics. If nickel enters the body with nickel contaminated air it is retained in the lungs. (9) Once it enters the body, nickel targets a number of organs, including the kidneys, lungs, and liver, and produces multiple toxic effects (9, 13). 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